Name: Piperine
IUPAC name: 1-[5-(1, 3-benzodioxol- 5-yl)-1-oxo-2, 4-pentadienyl]piperidine
Other names: 5-(3, 4-methylenedioxyphenyl)-2, 4-pentadienoyl-2-piperidine piperoylpiperidine
Molecular formula: C17H19NO3
Molecular weight: 285.34
CAS No: 94-62-2
Molar mass: 285.34 g mol− 1
Density: 1.193 g/cm3
Melting point: 130 ° C, 403 K, 266 ° F

Biological activity
The pungency caused by capsaicin and piperine is caused by activation of the heat and acidity sensing TRPV ion channel TRPV1 on nociceptors (pain sensing nerve cells).
Piperine has also been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. In animal studies, piperine also inhibited other enzymes important in drug metabolism. By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds. Notably, piperine may enhance bioavailability of curcumin by 2000% in humans.