Botanical Source
|
Naringin is the major flavonoid glycoside in grapefruit and gives grapefruit juice its bitter taste. It is metabolized to the flavanone naringenin in humans. Both naringenin and hesperetin, which are the aglycones of naringin and hesperidin, occur naturally in citrus fruits.
|
Pharmacological Function
|
A number of drugs that are known to be affected by the naringin in grapefruit include calcium channel blockers, estrogen,Anti-inflammatory, anti-virus, anti-mutagenic, anti-ulcer, cardiovascular and cerebrovascular diseases.sedatives, medications for high blood pressure, allergies,AIDS, and cholesterol-lowering drugs. Naringin exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of selected drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions in vivo.
|