Tipifarnib (trade name Zarnestra) is a farnesyltransferase inhibitor that is being investigated in patients 65 years
of age and older with newly diagnosed acute myeloid leukemia (AML). It inhibits the Ras kinase in a post translational
modification step before the kinase pathway becomes hyperactive. It inhibits prenylation of the CxxX tail motif,
which allows Ras to bind to the membrane where it is active. Without this step the protein cannot function.
It is also being tested in clinical trials in patients in certain stages of breast cancer.
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