Chemical Name: Paclitaxel
CAS Number: 33069-62-4
Molecular Formula: C 15 H 24 N 2 0 2
Molecular Weight: 264.36
Purity: 99% Appearance: white crystalline powder
Applications/Function :Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis.
Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes.
Items
Standard
Results
Characters
White or almost white crystalline powder
white crystalline powder
Specific rotation
-49.0~-55.0º
-52.6º
Identification
A:IR
Concordant with R.S
Complies
B:HPLC
IR Concordant with R.S
Complies
IMPURTTIES
Cephalomannine a1
sum of a1and a2 not more than 0.5%
0.105%
2,3-Dihydrocephaloman-nine a2
10-Deacetylbaccatin III
≤ 0.1 %
Complies
Baccatin III
≤ 0.2 %
0.094%
Photodegradant2
≤ 0.1 %
Complies
10-Deacetylpaclitaxel
≤ 0.5 %
Complies
2-Debenzoylpaclitaxel-2-pentenoate
≤ 0.7 %
0.108%
7-Epipaclitaxel
≤ 0.4
0.145%
10,13-Bissidechainpaclitaxel2
≤ 0.5 %
Complies
7-Acetylpaclitaxel
≤ 0.1 %
Complies
13-Tes-baccatin III
≤0.1%
Complies
7-Tes-paclitaxel
≤ 0.3 %
Complies
Any other single impurity
≤ 0.1 %
Complies
Total impurities
≤ 2.0 %
0.35%
Water
≤4.0%
0.8%
Residue on ignition
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