•Specifications
Offered as 10 mg
CAS Number: 502486-89-7
Molecular Weight: 459.37
Molecular Formula: C23H24Cl2N4O2
Physical Appearance: off-white solid
Solubility: Soluble in DMSO: ~16 mg/mL: water: insoluble
•Description
NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively].
•Storage
Store at 4˚C,
•For Research Use Only
•Reference Numbers
PubChem Compound ID: 11037861
•References
1.Lange, J.H.M. and Kruse, C.G., Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists Drug Discov. Today 10, 693-702, (2005) Katoch-Rouse, R., et al., Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity J. Med. Chem. 46, 642-645, (2003)
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