CAS: 75330-75-5 MF: C24H36O5 MW: 404.54 mp 175°C Refractive index: 320 ° (C=0.5, CH3CN) Storage temp.: 2-8°C Water Solubility : 0.0004 mg/mL at 25 ºC Chemical Properties :White Solid Usage :An antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase Biological Activity :Potent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro .
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