Cyclic polypeptide antibiotic produced by Bacillus polymyxa. Complex mixture of at least 30 components, primarily colistins A and B.
[α]D= -65° (c= 1, Water)
LOD: 3% DAB= α,γ-diaminobutyric acid
Heavy Metals: 20ppm Colistin A R= (+)-6-methyloctanoyl
Arsenic Content: 2ppm/g Colistin B R= 6-methylheptanoyl
Sulfate: 16-18%
Biological Potency (dry basis): 19600U/mg
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