Bromoconduritol selectively inhibits mammalian alpha-glucosidase 2 (Glc2/Glc1 glucosidase in the glycoprotein processing pathway), yeast alpha-glucosidase, and some beta-glucosidases. It does not inhibit mammalian alpha-glucosidase 1 (Glc3-glucosidase) or mammalian Golgi mannosidase 1 (alpha-1,2-specific) in the glycoprotein processing pathway; the formation of lipid-linked oligosaccharide precursor (dolichol pyrphosphate oligosaccharide) and the transfer of lipid-linked oligosaccharide to proteins.
Preparations in ice-cold H2O should be used immediately. The half-time for decomposition of bromoconduritol A (debromination) is 16 min (H2O, pH 7.3, 37oC). Under similar conditions, the half-life of bromoconduritol B is 2 mins. Working concentration for the inhibition of glycoprotein processing in vivo or in vitro is 2.5-5.0 mM.
Bromoconduritol may be used to alter the oligosaccharide chain composition of glycoproteins for studies on the role of oligosaccharides (especially hybrid or complex type oligosaccharides) in the transportability and function of glycoproteins.
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